Which drug is a DPP-4 inhibitor?

Which drug is a DPP-4 inhibitor?

• A. Sitagliptin
• B. Canagliflozin
• C. Pramlintide
• D. Exenatide

Answer: (A)

DPP-4 inhibitors work by blocking the enzyme that breaks down incretin hormones, mainly GLP-1 and GIP. By preventing their degradation, these hormones stay active longer, which enhances glucose-dependent insulin secretion and suppresses inappropriate glucagon release when glucose is high. Sitagliptin is a DPP-4 inhibitor, so it fits this mechanism by prolonging incretin action to improve blood sugar control. The other drugs use different approaches: canagliflozin is an SGLT2 inhibitor that increases urinary glucose excretion; pramlintide is an amylin analog that slows gastric emptying and lowers postprandial glucagon; exenatide is a GLP-1 receptor agonist that directly activates GLP-1 receptors.

DPP-4 inhibitors work by blocking the enzyme that breaks down incretin hormones, mainly GLP-1 and GIP. By preventing their degradation, these hormones stay active longer, which enhances glucose-dependent insulin secretion and suppresses inappropriate glucagon release when glucose is high. Sitagliptin is a DPP-4 inhibitor, so it fits this mechanism by prolonging incretin action to improve blood sugar control. The other drugs use different approaches: canagliflozin is an SGLT2 inhibitor that increases urinary glucose excretion; pramlintide is an amylin analog that slows gastric emptying and lowers postprandial glucagon; exenatide is a GLP-1 receptor agonist that directly activates GLP-1 receptors.